A multiscale investigation of motility-driven intestinal fluid transport in the application of transient permeability enhancers for drug absorption

  • Date: –13:00
  • Location: Online seminarium (via Zoom)
  • Lecturer: Benyamin Naranjani, SweDeliver
  • Website
  • Organiser: SweDeliver & NextBioForm
  • Contact person: Christel Bergström
  • Seminarium

In this SweDeliver & NextBioForm seminar Benyamin Naranjani will present his research within the field of Drug Delivery.

Abstract: In this project we will study the transport of biologics across the gastrointestinal tract using a physics-based multiscale approach. On the large scale, peptide drug molecules and permeation enhancers, added for increased bioavailability, are transported through the intestinal lumen by peristaltic/segmental motility patterns of the intestinal walls. After making their way across the mucus layer, they reach the intestinal epithelium layer, where nanoscale modeling is needed to acquire an understanding of the corresponding passage across the enterocytes. In this regard, two computational tools namely Lattice-Boltzmann Method (LBM) and Molecular Dynamics (MD) accounting for the macro and micro/nano scales respectively, will form the basis for the computer experimentations.

Researcher bio:  Benyamin Naranjani is a PhD student in the Drug Delivery group at Uppsala University, Sweden. With an engineering background, his research interest focuses on numerical simulations of fluid flow.

A multiscale investigation of motility-driven intestinal fluid transport in the application of transient permeability enhancers for drug absorption

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