Using 1H -NMR and all atom simulation to observe aggregation behavior of structurally similar peptides

  • Datum: –13.00
  • Plats: Online seminarium (via Zoom på https://uu-se.zoom.us/j/64018475310)
  • Föreläsare: Johanna Hjalte, Shakhawath Hossain, SweDeliver
  • Webbsida
  • Arrangör: SweDeliver & NextBioForm
  • Kontaktperson: Christel Bergström
  • Seminarium

Välkommen till SweDeliver & NextBioForm seminarieserie med fokus på forskning inom läkemedelstillförsel. Välkommen att delta online via https://uu-se.zoom.us/j/64018475310

Abstract: The aggregation behavior of a therapeutic peptide can have profound influence on several critical aspects of the pharmaceutical development and its use. In this work, we test the applicability of 1H NMR spectroscopy and all atom molecular dynamics simulations for investigating the aggregation behavior of structurally similar decapeptides, specifically D-Phe-GnRH, ozarelix, cetrorelix and degarelix, which are all analogs of gonadotropin releasing hormone (GnRH; a key peptide hormone in the human reproductive system).

Using 1H -NMR and all atom simulation to observe aggregation behavior of structurally similar peptides

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