Neuro seminar Benjamin Portal, Medical Neurobiology

  • Datum: –13.00
  • Plats: Zoom
  • Föreläsare: Benjamin Portal, Post doc, in Maria Lindskogs research group Medical Neurobiology
  • Webbsida
  • Arrangör: Dept of Neuroscience
  • Kontaktperson: Cecilia Yates
  • Telefon: +46704250571
  • Seminarium

Title: "Glutamate tuning in Alzheimer’s disease: from molecular observations to therapeutic applications"



Glutamate tuning in Alzheimer’s disease: from molecular observations to therapeutic applications

Background: It is increasingly clear that astrocytes can release gliotransmitters such as glutamate, ATP and D-serine at the synapse, as well as regulate other aspects such as neurotransmitter uptake and extracellular ion concentration, and thereby affect synaptic function. Despite already described astrocytic impairments in Alzheimer’s disease (i.e. neuroinflammation, high microglial activation), the role of astrocytes in regulating neurotransmission is still relatively unknown.
Methods: This project aims at exploring early astrocytic changes, with respect to synaptic regulation. From behavioral observations to detailed electrophysiological and immunohistochemical changes, the use of the state-of-the art mouse model of AD (APPNL-F) would help us to better understand early glial alterations.
Aims: Our preliminary data in 6-month-old APPNL-F mice show that already at this age, the mice display astrocytic morphological changes. These morphological changes may be associated to molecular and functional dysfunctions of astrocytes as we observed, in vitro, a reduction in the membrane potential of isolated neurons from 6-month-old mice. Going forward, we hypothesize that such morphological and molecular changes may affect astrocytes functions, in particular the gliotransmission. We think that a decrease in glutamate transporters (EAATs) and an increase in astrocytic glutamate release in AD may explain, at least in part, neuronal deficits in AD.

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